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Berberine+

Berberine+

Double action formula with tributyrin. Advanced metabolic and gut support using GlucoVantage® dihydroberberine — 5× more bioavailable than standard berberine HCL.
highlight icon GLUCOVANTAGE®
highlight icon COREBIOME®
highlight icon BANABA EXTRACT
highlight icon CHROMIUM

Delayed-Release Capsule · Targeted intestinal delivery · LIMITED TIME OFFER

Pre-Order • Ships June 2026

Your order reserves a spot in our first production batch and will ship once manufacturing and quality testing are complete.

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LIMITED FIRST BATCH
  • Third-party tested for purity

  • Delayed-release capsule technology

  • GMP-certified facility

  • Plant-based · Non-GMO

Description

For decades, berberine has been one of the most studied compounds in metabolic health — and one of the most poorly absorbed. Standard berberine HCL is rapidly metabolized before most of it reaches circulation, which is why meaningful results often require dosing 1,500mg+ per day, with the GI discomfort that comes with it. Arbor Berberine+ was built to solve that problem from the inside out.

Each delayed-release capsule delivers GlucoVantage® dihydroberberine — the active downstream metabolite of berberine — at a dose human pharmacokinetic research has shown can produce up to 5× greater plasma berberine exposure than equivalent standard berberine HCL. Less material, more uptake, dramatically better tolerability. Dihydroberberine works at the cellular level by activating AMPK (the body's metabolic master switch) and supporting endogenous GLP-1 secretion — two of the most discussed pathways in modern blood sugar and weight management research.

Absorption is only half the formula. Most berberine supplements stop there; Berberine+ adds CoreBiome® tributyrin, a clinically tested butyrate precursor that resists gastric breakdown and releases butyrate along both the small and large intestine, fueling colonocytes and supporting gut barrier integrity. It's a deliberate acknowledgment of the gut-metabolic axis: blood sugar regulation doesn't happen in isolation, and the microbiome plays a measurable role.

Rounding out the panel are two of the most well-validated metabolic compounds in the literature: Banaba Leaf Extract standardized to 2% corosolic acid for GLUT4 glucose transporter activation, and Chromium Picolinate (200 mcg) as an essential cofactor for insulin receptor signaling and macronutrient metabolism.

The capsule itself is engineered for delayed release, bypassing the stomach so each active lands where it can do the most work. No proprietary blends. No filler dosing. Plant-based, sugar-free, gluten-free, non-GMO, third-party tested, and produced in a GMP-certified U.S. facility. 60 capsules · 30-day supply · two patented branded ingredients · six metabolic pathways — engineered for serious daily use.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Shipping

We aim to deliver your wellness essentials quickly and safely.

  • Orders are processed within 1–2 business days
  • Delivery typically takes 3–7 business days, depending on your location
  • You will receive a tracking link once your order is shipped
  • We carefully package all products to ensure they arrive in perfect condition

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  • We offer a 7-day return window from the date of delivery
  • Products must be unused, unopened, and in original packaging
  • To initiate a return, please contact our support team with your order details
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What Makes Berberine+ Different

Standard berberine has a well-documented bioavailability problem. Berberine+ was formulated to solve it — and to go further with a dual gut-metabolic mechanism no standard berberine product offers.
  • GlucoVantage® dihydroberberine
    Up to 5× greater absorption than berberine HCL — the active metabolite form that activates AMPK and modulates GLP-1
  • CoreBiome® tributyrin
    Clinically tested tributyrin delivering butyrate to both the small and large intestine for gut barrier integrity
  • Delayed-release capsule
    Engineered to bypass gastric breakdown and release at the optimal point in the intestinal tract
What Makes Berberine+ Different

Clinically Researched Ingredients

Each capsule combines four science-backed compounds for comprehensive metabolic and gut support.

GlucoVantage®

GlucoVantage®

Dihydroberberine — 5× more bioavailable than standard berberine for enhanced AMPK activation

CoreBiome®

CoreBiome®

Tributyrin — targeted butyrate delivery to support gut barrier and the gut-metabolic axis

Banaba Extract

Banaba Extract

2% corosolic acid — activates GLUT4 transporters for efficient post-meal glucose clearance

Chromium

Chromium

Picolinate form — essential cofactor for insulin receptor signaling and macronutrient metabolism

Metabolic-image cinical-image

How It Works

Four metabolic mechanisms working simultaneously for comprehensive support.

01
AMPK activation

GlucoVantage® activates the body's metabolic master switch, supporting glucose uptake and energy balance

02
GLP-1 modulation

Dihydroberberine supports endogenous GLP-1 secretion, influencing insulin release and appetite signaling

03
GLUT4 glucose transport

Banaba leaf corosolic acid activates GLUT4 transporters, moving glucose from blood into cells

04
Gut-metabolic axis

CoreBiome® tributyrin feeds the colon microbiome, supporting gut barrier health and metabolic signaling

arbor image

Why Choose Arbor Berberine+

Clinically researched, fully transparent, and rigorously tested.

Patented branded ingredients
5× more bioavailable
Delayed-release capsule
Full ingredient transparency
GMP-certified facility
Third-party tested
Plant-based · Gluten-free
Sugar-free · Non-GMO

The Arbor Berberine Difference

See how Arbor Berberine+ compares to leading competitors.

Feature
Arbor Berberine+
Leading competitors
Berberine quality
GlucoVantage® dihydroberberine (highly bioavailable)
Generic berberine HCL (poor absorption)
Gut support
CoreBiome® tributyrin (promotes microbiome health)
None — often causes stomach upset
Capsule technology
Delayed-release (targeted intestinal delivery)
Standard capsules (quick dissolve)
Formula strength
Dual-action — metabolic + gut
Single ingredient — just berberine
Ingredients
Clinically researched, premium branded extracts
Generic / unverified standard extracts

Supplement Facts

Supplement Facts
Serving Size: 2 Delayed-Release Capsules
Servings Per Container: 30
Amount Per Serving % Daily Value**
Tributyrin (as CoreBiome®) 275 mg †
Dihydroberberine (as GlucoVantage®) 150 mg †
Banaba Leaf Extract (2% Corosolic Acid) 100 mg †
Chromium (as Chromium Picolinate) 200 mcg 571%**

** Percent Daily Values are based on a 2,000 calorie diet.

† Daily Value not established

Other Ingredients:Delayed-Release Vegetable Capsule (Hypromellose), Rice Flour, L-Leucine.

Directions:

Take two (2) capsules daily, preferably before your first meal, or as directed by a healthcare professional.

Ingredient Breakdown

GlucoVantage® Dihydroberberine +

GlucoVantage® uses dihydroberberine (DHB) — the active metabolite of berberine — which is absorbed up to 5× more efficiently than standard berberine HCL. Human pharmacokinetic research shows 200mg DHB produces significantly greater plasma berberine exposure than 500mg standard berberine. DHB also supports endogenous GLP-1 secretion through a naturally occurring metabolite pathway.

CoreBiome® Tributyrin +

CoreBiome® delivers tributyrin — a stable butyrate precursor — that resists gastric acid and releases butyrate along both the small and large intestine. Unlike sodium butyrate, which is absorbed before reaching the colon, CoreBiome® achieves verified colonic bioavailability, supporting microbiome balance and the gut-metabolic axis.

Banaba Leaf Extract +

Standardized to 2% corosolic acid, which activates GLUT4 glucose transporters — the cellular mechanisms responsible for moving glucose from blood into muscle and tissue. Supports efficient post-meal glucose clearance.

Chromium Picolinate +

An essential trace mineral required for normal insulin function. Chromium potentiates insulin receptor signaling and supports macronutrient metabolism, contributing to stable glucose utilization across carbohydrate, protein, and fat metabolism.

Frequently Asked Questions

What is the difference between GlucoVantage® and regular berberine? +

GlucoVantage® uses dihydroberberine (DHB), the active metabolite of berberine, which is absorbed up to 5× more efficiently than standard berberine HCL. Human pharmacokinetic research shows that 200mg DHB produces significantly greater plasma berberine exposure than 500mg standard berberine — meaning you get more of the active compound into circulation at a lower dose, with better GI tolerance.

What does CoreBiome® tributyrin do? +

CoreBiome® delivers tributyrin, a stable butyrate precursor that resists gastric acid and releases butyrate along both the small and large intestine. Butyrate is a short-chain fatty acid essential for gut barrier integrity and colonocyte energy production. Unlike sodium butyrate, which is absorbed before reaching the colon, CoreBiome® achieves verified colonic delivery — supporting microbiome balance and the gut-metabolic axis.

When should I take Berberine+? +

Take 2 capsules before your first meal of the day. GlucoVantage® dihydroberberine produces optimal glucose disposal effects when taken with or before meals. The delayed-release capsule technology ensures both GlucoVantage® and CoreBiome® are delivered at the right point in the intestinal tract regardless of timing.

Is Berberine+ safe to take with medications? +

If you are taking prescription medications — particularly for blood sugar management, blood pressure, or anticoagulation — consult your healthcare provider before use. Berberine compounds can interact with certain medications. These statements have not been evaluated by the FDA.

How long before I notice results? +

Metabolic support supplements work best when taken consistently over time. Clinical research on berberine compounds typically shows measurable effects on glucose metabolism markers within 4–8 weeks of consistent daily use. Individual results vary.

Can I take this with Sugar Balance Gummies? +

Yes. Berberine+ and Sugar Balance Gummies target complementary metabolic pathways and are designed to work together. Always consult your healthcare provider before combining supplements.

The Most Complete Berberine Formula Available

GlucoVantage® + CoreBiome® + Delayed-release capsule — 60 capsules, 30-day supply.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.